1525 Combination of adipose stem cell exosomes (ASCE) with CO2 laser for acne scars: A 12-week prospective, double-blind, randomized, split-face study

Objectives: To find the clinical efficacy and safety of adipose tissue stem cell exosomes as an adjuvant therapy after application fractional CO2 laser for acne scars. Introduction:While ablative FCL resurfacing has demonstrated in scar treatment, patients need better improvement scars sustain side-effects post-procedural wound healing. Therefore, ASCE been tried, with synergistic effects augmenting treatment responses reducing adverse through its potential to accelerate regeneration Material/Method:25 subjects atrophic scars(ECCA scores 50<) were enrolled. The entire face each patient was treated 10,600-nm FCL. parameters determined based on patient’s condition follows: 7.2–9.0 mJ, 240–300 μs duration, 0.8–1.0 mm density All 1 ml either gel or control half according random assignment finishing treatment. For next two days instructed apply solution designated twice a day. Results:ASCE side had significant reduction ECCA score from baseline at first posttreatment visit second post-treatment visit. At final visit, reduced by 32.5% ASCE, which significantly greater than Mean reductions analyzed subtype scar. Both V- U-shaped decreases both sides, however M- shaped ASCE-treated showed improvement. Conclusion:ASCE more favorable responses, shorter recovery time, fewer combination scarring. co-treatment this novel material devices may provide treatments.